background: axotomy causes sensory neuronal loss. reconnection of proximal and distal nerve ends by surgical repair improves neuronal survival. it is important to know the morphology of primary sensory neurons after the surgical repair of their peripheral processes. methods: animals (male wistar rats) were exposed to models of sciatic nerve transection, direct epineurial suture repair of sciati...

Neurite outgrowth from dorsal root ganglion (DRG) explants is a method of evaluating neurotrophic activity of growth factors. When complete medium containing collagen was supplemented with nerve growth factor (NGF) DRG outgrowth was observed after 18 h. In the absence of NGF and in the presence of collagen, the DRG outgrowth took place after 72 h. In wells not supplemented with collagen gel in ...

neurite outgrowth from dorsal root ganglion (drg) explants is a method of evaluating neurotrophic activity of growth factors. when complete medium containing collagen was supplemented with nerve growth factor (ngf) drg outgrowth was observed after 18 h. in the absence of ngf and in the presence of collagen, the drg outgrowth took place after 72 h. in wells not supplemented with collagen gel in ...

Dorsal root ganglion stimulation (DRG-S) is a promising therapy for chronic neuropathic pain, but complications of this are poorly understood. Twiddler's syndrome, rare complication characterized by lead displacement and coiling wires, has been reported in other neuromodulation devices, not described the context DRG-S. Here, we present first-of-a-kind case report syndrome occurring after 8 mont...

A laterally herniated disk, spinal stenosis, and various degenerative or traumatic diseases of the spine can sometimes lead to a chronic compression and inflammation of the dorsal root ganglion and chronic abnormal sensations including pain. After a chronic compression of the dorsal root ganglion (CCD) in rats, the somata in the dorsal root ganglion (DRG) become hyperexcitable, and some exhibit...

Sacral stimulation is a well-established therapy for urologic neuromodulation. After the advent of dorsal root ganglion (DRG) stimulation, pain surgeons have started to reach this target mostly pelvic and sacral pain. For those without good surgical experience, foramen puncture, especially S3 S4, can be challenge, due its entry angle limited C-arm image resolution. In report, we describe new te...

During development, dorsal root ganglion (DRG) neurons in higher vertebrates extend their axons centrally to the spinal cord through the dorsal root entry zone (DREZ) and peripherally to muscle and skin targets. After entering the spinal cord, DRG axons project into the dorsal mantle layer. In this review, we focus on evidence showing the role for netrin-1 in forming sensory axonal trajectories...

Mechanical property is an important factor of cellular microenvironment for neural tissue regeneration. In this study, polyacrylamide (PAM) hydrogels with systematically varying elastic modulus were prepared using in situ radical polymerization. We found that the hydrogel was biocompatible, and length dorsal root ganglion (DRG)'s axon cell density optimal on 5.1 kPa (among between 3.6 16.5 kPa)...